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KMID : 0043319870100040232
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Archives of Pharmacal Research
1987 Volume.10 No. 4 p.232 ~ p.238
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Refinement of the Structure of Naproxen, (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
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Kim YB
Song HJ/Park IY
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Abstract
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The molecular structure of naproxen determined by X-ray diffraction technique was refined to the final R-value being 0.042. The compound was recrystallized from ethanol solution in monoclinic crystal system, space group P21, with Z=2, a=13.375(5)angstroem, b=5.793(2)angstroem, c=7.914(3)angstroem, beta=93.91(3)angstroem and dobs=1.26, dcalc=1.25g/cm3. The structure was solved by direct method and refined by block diagonal least squares procedure for 747 reflections(F > or = 6sigma(F)). The molecules are connected by two intermolecular OH--O type hydrogen bonds.
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KEYWORD
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